Have any of you done this or plan to do it at all?
bikepacking.com
I think it would be a lot of fun! Break it up in a few days or do and out and back if you can handle the daily mileage.

Little Egypt River to River
Photos by Antonio Martinez The region of southernmost Illinois known as “Little Egypt” has several unique features highlighted on this river-to-river route. Historically, it’s where the state’s European settlements began. Cairo (pronounced locally as “care-oh”) was a thriving Illinois river port...
I think it would be a lot of fun! Break it up in a few days or do and out and back if you can handle the daily mileage.